Bioavailability of Flavonoids and Phenolic Acids From Cranberry Juice Cocktail in Healthy Older Adults
Completed · Not applicable
Conditions studied: Healthy
In brief
This is a single-dose, pharmacokinetic study investigating the bioavailability of flavonoids and phenolic acids from cranberry juice cocktail and their breakdown products (in vivo metabolites) in healthy, older adults. Our hypothesis is that the compounds will be poorly but rapidly absorbed from the intestines and found in plasma and urine in extensively metabolized forms. These compounds will be rapidly cleared from plasma. Substantial amounts of unabsorbed compounds will be found in the stools.
Key facts
- Study ID
- NCT00740077
- Run by
- Tufts University
- People needed
- 10
- Starts
- 2008-08-01
- Expected to finish
- 2009-01-01
- Last updated by the study team
- 2009-02-09
Who can join
Age: 50 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and postmenopausal women
- BMI 18.5-29.9 kg/m2
You may not qualify if…
- Cigarette smoking and/or nicotine replacement use
- Use of cholesterol-lowering medications
- Use of blood pressure-lowering medications
- Use of any stomach acid-lowering medications
- Cardiovascular (heart) disease
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure > 150 mm Hg and/or diastolic blood pressure > 95 mm Hg
- Regular use of oral steroids
- Regular daily intake of 2 or more alcoholic drinks
- Illicit drug use
- No fish oil supplements (including cod liver oil) for one month prior to study admission
- No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
Where it is running
- Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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