In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter

Stopped early

Conditions studied: GERD, Barretts Esophagus

In brief

The purpose of this study is: * To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth muscle components. * To differentiate the gastric sling fibers from the clasp fibers based on the spatial orientation of these muscle groups.

Key facts

Study ID

NCT00737802

Run by

Northwell Health

People needed

4

Starts

2013-04-12

Expected to finish

2017-02-03

Last updated by the study team

2019-02-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion criteria for GERD patients are:
• Symptomatic heartburn
• Regurgitation
• Chest pain or water brash

You may not qualify if…

• Exclusion criteria for normal volunteers include:
• Medications-Subjects on any medication which could effect the gastroesophageal junction high-pressure zone will be excluded, this includes use of antacids, H2 blockers, proton pump inhibitors, prokinetic agents, erythromycin type antibiotics and anticholinergics.
• GI symptoms, conditions and disorders
• In addition exclusion criteria will include a history of:
• Esophagitis
• Gastrointestinal symptoms such as abdominal pain
• Heartburn
• Reflux
• Regurgitation
• Chest pain
• Difficulty swallowing
• Pain on swallowing
• Dysphagia
• Abdominal surgery involving the stomach or esophagus
• Nausea or vomiting
• Diabetes
• Scleroderma
• Esophageal motility disorders
• Non cardiac chest pain
• Achalasia and current pregnancy.

Where it is running

• LIJ Medical Center- NSLIJ Health System — New Hyde Park, New York, United States

Full record on ClinicalTrials.gov

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