Does Echocardiographically Guided Ventriculo-Ventricular Optimization Yield a Sustained Improvement in Echocardiographic Parameters in Cardiac Resynchronization Therapy Patients? (DEVISE CRT)

Completed · Not applicable

Conditions studied: Cardiomyopathy, Heart Failure

In brief

The purpose of this study is to determine whether using an echocardiogram (a painless test where ultrasound is used to see your heart) while using mild electrical stimulation from your own CRT-D device to stimulate the ventricles (the lower chambers of the heart) to squeeze one slightly earlier than the other will show a sustained increase your heart's productivity (Cardiac Output (CO)), following implantation of a Cardiac Resynchronization Device (CRT-D). We believe that squeezing some parts of the heart earlier than others may make the heart a stronger pump.

Key facts

Study ID

NCT00737490

Run by

Duke University

People needed

40

Starts

2005-06-01

Expected to finish

2011-07-01

Last updated by the study team

2014-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• LVEF </= 35% as assessed by echocardiography.
• New York Heart Association Functional Class III or IV CHF despite contemporary medical therapy for CHF.
• QRS duration of >/= 120 ms.
• Ability to provide written, informed consent.
• Age > 18 years.
• Successful implant of a biventricular/ICD pacemaker device.

You may not qualify if…

• Documented Chronic Atrial Fibrillation
• Life expectancy less that 6 months due to non-cardiac causes
• Inability to place a coronary sinus left ventricular pacing lead
• Pregnancy
• Scheduled cardiac surgery within the next 6 months
• Prosthetic Tricuspid Valve

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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