Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
Stopped early · Not applicable
Conditions studied: Osteoarthritis
In brief
This study involves research. The purpose of this research is to formally investigate the hemostatic efficacy of epinephrine to minimize blood loss after total joint arthroplasty. It is unclear if using intra-articular injections of epinephrine in total joint replacement is associated with a decrease in post-operative blood loss. The initial hypothesis is: the use of intra-articular injection of epinephrine is associated with decreased post-operative blood loss.
Key facts
- Study ID
- NCT00737139
- Run by
- Rush University Medical Center
- People needed
- 33
- Starts
- 2008-09-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2012-08-31
Who can join
Age: 19 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients must be male or female of any race
- Ages 18-80yr
- Patients must be undergoing hip or knee arthroplasty
- Patients must be able to understand and be willing to cooperate with study procedures
- Patient must not take platelet inhibiting drugs for 10 days before surgery
- Able to provide written and verbal informed consent
- Preoperative hemoglobin above 12g/dl
- Osteoarthritis as the primary indication for knee arthroplasty, and either osteoarthritis or avascular necrosis as the indication for total hip arthroplasty
You may not qualify if…
- Allergy or intolerance to the study materials or medications
- Surgical intervention during the past month for the treatment of the painful joint or its underlying etiology
- History of any substance abuse or dependence within the last 6 months
- Patients who have received an investigational drug or device in the past 30 days
- Affected joint has undergone prior open surgery
- Patient received epoetin alfa 30 days before surgery
- Pre-operative autologous blood donation
- Use of platelet inhibiting drugs 10 days prior to surgery
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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