Vitamin D, Insulin Resistance, and Cardiovascular Disease

Completed · Not applicable · Has a placebo group

Conditions studied: Vitamin D Deficiency, Insulin Resistance, Type 2 Diabetes Mellitus, Cardiovascular Disease, Hypertension

In brief

In recent years, vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease in patients with diabetes. Epidemiological studies indicated the high prevalence of vitamin D deficiency among Type 2 DM patients and suggest an increased risk of cardiovascular disease and hypertension with low vitamin D levels. The objective of this proposal is to evaluate the effects of vitamin D replacement on blood pressure control and vascular disease in vitamin D deficient hypertensive patients with diabetes

Key facts

Study ID

NCT00736632

Run by

Washington University School of Medicine

People needed

125

Starts

2006-05-01

Expected to finish

2019-01-13

Last updated by the study team

2020-02-10

Who can join

Age: 25 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 diabetes
• 25 (OH) vitamin D levels < 25 ng/ml
• Age 25 to 80 years
• Not on insulin for diabetes treatment
• HbA1c 5.5% -9.5%
• Mild/moderately increased blood pressure (systolic 120-160, diastolic 80-100) off BP medications

You may not qualify if…

• Pregnancy
• Patients with systolic >160 or diastolic >100 mmHg
• High urine calcium or history of recurrent kidney stones
• Cardiovascular disease
• Stage 3 or worse chronic kidney disease

Where it is running

• Washington Universiy — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.