Memory and Picture Viewing Study

Completed

Conditions studied: Healthy, Brain Reactivity of Non-smokers Undergoing fMRI Scanning

In brief

The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Key facts

Study ID

NCT00736203

Run by

Duke University

People needed

116

Starts

2008-07-01

Expected to finish

2011-11-01

Last updated by the study team

2013-02-07

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• generally healthy
• right-handed non-smokers
• between the ages of 18-55
• an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker)
• having smoked < 50 cigarettes in their lifetime

You may not qualify if…

• inability to attend all sessions
• significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems)
• use of psychoactive medications
• use of any tobacco or nicotine containing products
• current alcohol or drug abuse
• use of illegal drugs as measure by a urine drug screen
• presence of conditions that would make MRI unsafe (pacemaker, metallic implants

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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