Comparing Efficacy and Safety of Combigan With Timolol Adjunctive to Xalatan in Glaucoma or Ocular Hypertension Subjects
Completed · Phase 4
Conditions studied: Glaucoma, Ocular Hypertension
In brief
Efficacy and safety evaluation of Combigan with timolol when each is used as adjunctive therapy to Xalatan in subjects with glaucoma or ocular hypertension.
Key facts
- Study ID
- NCT00735449
- Run by
- Allergan
- People needed
- 204
- Starts
- 2008-07-01
- Expected to finish
- 2009-12-01
- Last updated by the study team
- 2019-04-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Be at least 18 years of age
- Give written informed consent
- Be in good general health as determined by your doctor
- Have a diagnosis of unilateral or bilateral glaucoma or ocular hypertension
- If you are a female of child bearing potential, you must be willing to practice effective contraception for the duration of the study (i.e., abstinence, spermicide, condoms, or birth control pills)
- Understand the study instructions, and be able to follow the study instructions; and
- Be likely to complete the entire study period (12 weeks), including all regularly scheduled study visits
You may not qualify if…
- Have any active ocular disease other than glaucoma or ocular hypertension that would interfere with study interpretation
- History of severe renal or hepatic impairment
- Subjects with severe cardiovascular disease should not be enrolled unless their disease is controlled and clearance has been obtained from the subject's primary care physician and/or cardiologist
- Contraindications to beta-adrenoceptor antagonist therapy such as chronic obstructive pulmonary disease, bronchial asthma, sinus bradycardia, second and third degree atrioventricular block, overt cardiac failure and cardiogenic shock or uncontrolled congestive heart failure
- Any systemic disease or clinical evidence of any condition which would make the subject, in the opinion of the investigator, unsuitable for the study or could potentially confound the study results; and
- Concurrent participation or prior participation in any investigational drug or device study within the last 30 days prior to the screening visit
Where it is running
- Study site — Newark, New Jersey, United States
- Study site — Montreal, Quebec, Canada
Full record on ClinicalTrials.gov
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