Gemcitabine and Erlotinib Before and After Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery

Completed · Phase 2

Conditions studied: Pancreatic Cancer

In brief

PURPOSE: This phase II trial is studying how well gemcitabine and erlotinib work when given before and after surgery in treating patients with pancreatic cancer that can be removed by surgery. Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving gemcitabine and erlotinib before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving these drugs after surgery may kill any tumor cells that remain after surgery.

Key facts

Study ID

NCT00733746

Run by

Alliance for Clinical Trials in Oncology

People needed

123

Starts

2009-04-01

Expected to finish

2019-06-15

Last updated by the study team

2019-10-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• Kaiser Permanente Medical Center - Los Angeles — Los Angeles, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California, United States
• St. Vincent's Medical Center — Bridgeport, Connecticut, United States
• Lakeland Regional Cancer Center at Lakeland Regional Medical Center — Lakeland, Florida, United States
• St. Francis Hospital Cancer Care Services — Indianapolis, Indiana, United States
• Alvin and Lois Lapidus Cancer Institute at Sinai Hospital — Baltimore, Maryland, United States
• St. Agnes Hospital Cancer Center — Baltimore, Maryland, United States
• University of Mississippi Cancer Clinic — Jackson, Mississippi, United States
• Methodist Estabrook Cancer Center — Omaha, Nebraska, United States
• NYU Cancer Institute at New York University Medical Center — New York, New York, United States
• Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill — Chapel Hill, North Carolina, United States
• David L. Rike Cancer Center at Miami Valley Hospital — Dayton, Ohio, United States
• Samaritan North Cancer Care Center — Dayton, Ohio, United States
• CCOP - Dayton — Dayton, Ohio, United States
• Charles F. Kettering Memorial Hospital — Kettering, Ohio, United States
• UVMC Cancer Care Center at Upper Valley Medical Center — Troy, Ohio, United States
• Natalie Warren Bryant Cancer Center at St. Francis Hospital — Tulsa, Oklahoma, United States
• Providence Cancer Center at Providence Portland Medical Center — Portland, Oregon, United States
• Gibbs Regional Cancer Center at Spartanburg Regional Medical Center — Spartanburg, South Carolina, United States
• Surgical Oncology Associates — Newport News, Virginia, United States
• Mary Babb Randolph Cancer Center at West Virginia University Hospitals — Morgantown, West Virginia, United States
• University of Wisconsin Paul P. Carbone Comprehensive Cancer Center — Madison, Wisconsin, United States
• Princess Margaret Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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