Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

Completed · Not applicable

Conditions studied: Sleep Apnea, Age

In brief

The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly. This proposal focused on key factors that contribute to the control of ventilation in elderly adults during sleep. The investigators studied the age-specific changes in ventilatory control in older and young adults during NREM sleep.

Key facts

Study ID

NCT00732199

Run by

VA Office of Research and Development

People needed

92

Starts

2008-10-01

Expected to finish

2015-04-01

Last updated by the study team

2017-06-28

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy older and young adults

You may not qualify if…

• Pregnancy,
• history of active coronary artery disease-including stable and unstable angina,
• recent myocardial infarction,
• history of congestive heart failure,
• stroke,
• excessive daytime sleepiness with Epworth Sleepiness Scale of >15
• patient with OSA- (Obstructive sleep apnea) on therapy
• depression,
• schizophrenia,
• untreated hypothyroidism,
• diabetes on insulin,
• seizure disorder,
• intrinsic renal and liver disorders,
• failure to give informed consent,
• patients with evidence of pulmonary diseases based on history and abnormal pulmonary function testing, including obstructive (ratio of predicted forced expiratory volume to forced vital capacity, <80% predicted) or restrictive lung disorders (total lung capacity <80% predicted) with resting oxygen saturation of <96% and kyphoscoliosis (chest wall deformities)
• patients on certain medications including, opiates derivatives, stimulants, antidepressants, tranquilizers, anti-psychotic agents, theophylline and other central nervous system altering medications
• history of alcohol or recreational drug use will also serve as grounds for exclusion,
• patients with body mass index (BMI) >34kg/m2
• subjects with sleep apnea are already using continuous positive airway pressure for more than 7 days as therapy

Where it is running

• John D. Dingell VA Medical Center, Detroit, MI — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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