Effects of Varenicline on Cigarette Self Administration

Completed · Phase 2 · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

The investigators hypothesize that varenicline will dose dependently attenuate the subjective effects of cigarettes after a period of abstinence. Also, treatment with varenicline will dose dependently weaken the severity of nicotine withdrawal symptoms. Thirdly, we hypothesize that treatment with varenicline will dose dependently decrease cigarette self-administration in the model proposed.

Key facts

Study ID

NCT00731055

Run by

New York State Psychiatric Institute

People needed

16

Starts

2008-02-01

Expected to finish

2009-05-01

Last updated by the study team

2018-06-18

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• A diagnosis of nicotine dependence with physiological dependence, smoking at least 15 cigarettes/day during the last 3 months.
• Not interested in treatment
• Medically healthy on the basis of physical examination and medical history, vital signs, EKG and laboratory tests, with a negative pregnancy test for females.
• Able to perform study procedures
• Males or females between the ages of 21-45 yrs
• Female participants agree to use an effective method of birth control during the course of the study

You may not qualify if…

• A diagnosis of abuse or dependence on alcohol or drugs other than nicotine
• Current Axis I diagnosis or current treatment with psychotropic medications (within last 3 months)
• Lifetime history of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety disorders
• Currently seeking treatment for nicotine dependence
• Participants on parole or probation
• History of significant recent violent behavior
• Blood pressure > 150/90
• History of allergic reaction to any of the study medications

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.