Genetic Predictors of Raltegravir Penetration Into Cerebrospinal Fluid

Completed · Phase 2/Phase 3

Conditions studied: HIV Infections

In brief

This study is being done to find out how much of the drug raltegravir (RGV) gets into cerebrospinal fluid (CSF), compared to how much get into the blood and to find out if normal changes in a certain gene in your body affects how much RGV gets into the CSF.

Key facts

Study ID

NCT00729924

Run by

Vanderbilt University

People needed

40

Starts

2008-08-01

Expected to finish

2011-08-01

Last updated by the study team

2015-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to give informed consent.
• Negative HIV-1 serology.
• At least 18 but no more than 55 years of age.
• Body mass index <30.
• Estimated creatinine clearance ≥ 50 mL/minute within 30 days prior to study entry.
• Within 30 days prior to study entry:
• Absolute neutrophil count ≥ 1,000/mm3.
• Hemoglobin ≥ 12.5 g/dL for males and ≥ 11.5 g/dL for females.
• Platelet count ≥ 100,000/mm3.
• AST, ALT, and total bilirubin within normal range.
• Alkaline phosphatase < or = 1.5 x upper limit of normal.
• Female study volunteers of reproductive potential must have a negative serum or urine pregnancy test performed within 30 days before study entry.
• Must agree not to participate in a conception process.
• Drug transporter gene ABCB1 position 3435 genotype C/C or T/T.

You may not qualify if…

• Use of any medication that is metabolized by CYP3A or UGT1A1.
• Anticipated need to take any medication that is metabolized by CYP3A or UGT1A1 during the study.
• Active drug use or dependence.
• Inability to abstain from alcohol-containing beverages, grapefruit, and grapefruit juice.
• Serious illness that would interfere with study participation.
• Hospitalization for any reason or therapy for serious illness within 14 days prior to study entry.
• History of hypersensitivity to study drug or its formulation.
• As determined by the investigator, a significant active or previous history of cardiovascular, renal, liver, hematologic, neurologic, gastrointestinal, psychiatric, endocrine, or immunologic disease(s). This is inclusive of chronic illnesses such as hypertension, coronary artery disease, arthritis, diabetes, any chronic gastrointestinal conditions that may affect drug absorption, etc.
• Breast-feeding.
• Evidence of CNS infection or space occupying lesion by history or physical examination.
• History of significant CNS disorder.
• Prisoners or subjects who are compulsorily detained.
• ABCB1 position 3435 C/T heterozygosity.

Where it is running

• Vanderbilt Therapeutics Clinical Research Site — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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