Study of GSK1363089 in Metastatic Gastric Cancer

Completed · Phase 2

Conditions studied: Neoplasms, Gastrointestinal Tract

In brief

This clinical study is being conducted at multiple sites to determine the best confirmed response rate, safety, and tolerability of GSK1363089 treatment in metastatic gastric carcinoma.

Key facts

Study ID

NCT00725712

Run by

GlaxoSmithKline

People needed

74

Starts

2007-03-31

Expected to finish

2009-11-30

Last updated by the study team

2017-08-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• histologically confirmed diagnosis of advanced or metastatic gastric carcinoma, or adenocarcinoma of the gastroesophageal junction or of the distal esophagus. Subjects with tumors of the gastroesophageal junction or of the distal esophagus may be eligible provided that the tumor is not of squamous or sarcomatous histology
• Measurable disease
• The subject consents to provide paired tumor biopsies, directly prior to commencing study treatment and then between Days 5 and 8.
• The subject has an ECOG performance status ≤2.
• The subject is able to ingest the GSK1363089 capsules.
• In the adrenocorticotropic hormone (ACTH) stimulation test, the subject has a serum cortisol level ≥20 μg/dL (552 nmol/L) 30-90 minutes after injection of ACTH.
• The subject has liver, kidney and marrow function.
• The subject is capable of understanding and complying with the protocol and has signed the informed consent document.
• Sexually active subjects (male and female) must use a medically-accepted method of contraception during the course of the study.
• Female subjects of childbearing potential must have a negative serum pregnancy test at screening.
• The subject has had no other diagnosis of malignancy (unless non-melanoma skin cancer or a malignancy diagnosed ≥5 years ago, and has no evidence of disease for 5 years prior to the screening for this study).
• QTc < 470 msec.

You may not qualify if…

• The subject has received more than two lines of prior cytotoxic chemotherapy for locally advanced or metastatic disease. For the purpose of this protocol, neoadjuvant therapy would not be considered to be prior cytotoxic chemotherapy. In addition, potential subjects who have received prior treatment with c-MET signaling inhibitor are excluded.
• The subject has received an investigational drug within 14 days of the first dose of study drug.
• The subject has received chemotherapy, immunotherapy, or radiation therapy (to
• ≥25% of his or her bone marrow) within 14 days or has received nitrosoureas or mitomycin C within 6 weeks prior to the scheduled first dose of GSK1363089.
• The subject has AEs due to investigational drugs or other medications administered more than 21 days prior to enrollment that have not recovered to Grade ≤1 using NCI CTCAE v3.0, with the exception of alopecia greater than grade 1.
• The subject has known brain metastases.
• The subject has uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• The subject is pregnant or breastfeeding.
• The subject is known to be positive for the human immunodeficiency virus (HIV).
• The subject has a previously identified allergy or hypersensitivity to components of the GSK1363089 formulation.
• The subject is unable or unwilling to abide by the study protocol or cooperate fully with the investigator or designee.

Where it is running

• GSK Investigational Site — Birmingham, Alabama, United States
• GSK Investigational Site — Scottsdale, Arizona, United States
• GSK Investigational Site — Los Angeles, California, United States
• GSK Investigational Site — Stanford, California, United States
• GSK Investigational Site — Washington D.C., District of Columbia, United States
• GSK Investigational Site — Atlanta, Georgia, United States
• GSK Investigational Site — Chicago, Illinois, United States
• GSK Investigational Site — Boston, Massachusetts, United States
• GSK Investigational Site — Detroit, Michigan, United States
• GSK Investigational Site — Billings, Montana, United States
• GSK Investigational Site — Albuquerque, New Mexico, United States
• GSK Investigational Site — New York, New York, United States
• GSK Investigational Site — New York, New York, United States
• GSK Investigational Site — Durham, North Carolina, United States
• GSK Investigational Site — Portland, Oregon, United States
• GSK Investigational Site — Austin, Texas, United States
• GSK Investigational Site — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.