A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma

Completed · Phase 1

Conditions studied: Malignant Solid Tumor, Lymphomas, Multiple Myeloma

In brief

Phase 1 study to determine safety, tolerability, dose-limiting toxicities (DLTs), and recommended Phase 2 dose of AV-299 administered IV as monotherapy to patients with relapsed or refractory solid tumors, lymphoma, or multiple myeloma. The study will also determine the safety, tolerability and DLTs of AV-299 in combination with erlotinib in patients with relapsed or refractory solid tumors.

Key facts

Study ID: NCT00725634
Run by: AVEO Pharmaceuticals, Inc.
People needed: 41
Starts: 2008-09-01
Expected to finish: 2013-12-01
Last updated by the study team: 2014-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of an advanced solid tumor malignancy or lymphoma (non-Hodgkin's or Hodgkin's lymphoma).
Histological or cytological evidence of malignancy.
Advanced malignancy, metastatic or unresectable, that has recurred or progressed following standard therapy or failed standard therapy; or for which no standard therapy currently exists, or for which subject is not a candidate for, or is unwilling to undergo, standard therapy.
Disease that is currently not amenable to curative surgical intervention.
ECOG performance status of 0-1. Subjects with performance status of 2 will be considered only after discussion between the investigator and medical monitor.
18 years or older, of either sex, and of any race.
Subject (and/or parent/guardian for subject who otherwise is unable to provide independent consent, if acceptable to and approved by the site and/or site's IRB) must be willing to give written informed consent and be able to adhere to dose and visit schedules.
Female subjects of childbearing potential must have negative pregnancy test within 5 days prior to first dose of study drug.
Female subjects of childbearing potential and male subjects whose sexual partners are of childbearing potential must agree to abstain from sexual intercourse or to use an effective method of contraception during the study and for 60 days after the last dose of AV-299 (formerly SCH 900105). Examples of effective methods of contraception include, but are not limited to, oral contraceptives or double barrier methods such as condom plus spermicide or condom plus diaphragm.
Adequate hematologic function as evidenced by Hg ≥ 9g/dL, WBC ≥ 3000 per mm3, ANC ≥ 1500 per mm3 and platelet count ≥ 100,000 per mm3.
Adequate hepatic function as evidenced by a serum bilirubin level ≤1.5 × ULN (except with known Gilbert's Syndrome) and
For subjects in the dose-escalation cohorts and the Phase 1b evaluation of AV-299 (formerly SCH 900105) in combination with erlotinib:
- Serum AST/ALT levels ≤3 × ULN for the reference laboratory
For subjects in the RP2D safety expansion cohort:
Without known hepatic metastasis serum AST/ALT levels ≤3 × ULN for the reference laboratory
With known hepatic metastasis serum AST/ALT levels ≤5 × ULN.
Adequate renal function as evidenced by a serum creatinine level ≤ 1.5 × ULN or a calculated creatinine clearance > 60 mL/min.
Adequate coagulation function as evidenced by PTT ≤ 1.5 × ULN and INR ≤ 1.5 × ULN
Recovery from the effects of any prior surgery, radiotherapy, or systemic antineoplastic therapy.
Subjects with abnormal liver function tests (LFTs) who have not been screened for Hepatitis B or C within the past 6 months prior to study enrollment, will need to be screened for Hepatitis B and C and can only be enrolled if the screening is negative.
Diagnosis and Main Criteria for Inclusion for the Multiple Myeloma Exploratory Cohort Subjects to be Included
Diagnosis of symptomatic relapsed or refractory multiple myeloma. Note: For relapsed disease, subject must have PD after having achieved at least stable disease for ≥ 1 cycle of treatment to ≥ 1 prior regimen. For refractory disease, subject must have documented evidence of PD during or within 60 days (measured from the end of the last cycle) of completing treatment with the last anti-myeloma drug regimen used just prior to study entry.
Measurable disease assessed by one of the following:
Serum monoclonal protein ≥ 1.0 g/dL by protein electrophoresis;
> 200 mg of monoclonal protein in the urine on 24 hour electrophoresis;

You may not qualify if…

Women who are breast-feeding, pregnant, or intend to become pregnant.
Subjects with primary CNS malignancy or symptomatic CNS metastases, with the exception that subjects with glioblastoma multiforme may be enrolled in the RP2D Safety Expansion Cohort and in the Phase 1b evaluation of AV-299 (formerly SCH 900105) in combination with erlotinib. Subjects with treated brain metastases that have remained stable for at least 3 months without steroids are allowed. Subjects with signs or symptoms or history of brain metastasis must have a CT or MRI scan of the brain within 1 month prior to the first dose of study drug. Subjects with spinal cord or nerve root compression who have completed treatment at least 4 weeks prior to the first dose of study drug and are stable without steroid treatment for at least 1 week prior to the first dose of study drug are allowed. Subjects with leptomeningeal metastases are not allowed.
Hematologic malignancies other than lymphoma
Any of the following within 6 months prior to administration of study drug:
Myocardial infarction (MI), severe /unstable angina pectoris, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack or seizure disorder.
Serious and/or symptomatic active infection within 14 days prior to first dose of study drug. Subjects who have asymptomatic or mild infection and taking a short course of antibiotics (ie, UTI, bronchitis) may be allowed after discussion with the medical monitor.
Baseline QTc interval as follows per Bazett's formula: Females > 470 msec; Males > 450 msec.
Persistent, unresolved CTCAE v3.0 Grade 2 or higher drug-related toxicity (except alopecia, erectile dysfunction, hot flashes, and decreased libido) associated with previous treatment.
Inadequate recovery from any prior surgical procedure or major surgical procedure performed within 4 weeks prior to administration of first dose or major surgery within 3 weeks prior to first dose of study drug.
Any other medical or psychiatric condition that, in the opinion of the investigator, might interfere with the subject's participation in the trial or interfere with the interpretation of trial results.
Known Human Immunodeficiency Virus (HIV) infection or a known HIV-related malignancy.
Known active hepatitis B or C.
Known hypersensitivity to any of the components of AV-299 (formerly SCH 900105).
Radiotherapy within 3 weeks prior to first study drug administration.
Inability to comply with the protocol requirements or participation in any other clinical study.
Any medications listed in the table on "Prohibited Medications".
Active alcohol abuse.
Stem cell/bone marrow transplant within 6 months of first dose of study drug.
Additional Exclusion Criteria for Subjects Enrolled in the Phase 1b Evaluation of AV-299 (formerly SCH 900105) in Combination with Erlotinib:
Inability to take oral medications
Grade 2 or higher diarrhea at baseline, or inflammatory bowel disease
Any gastrointestinal disorder that may interfere with the absorption of oral medications
Acute onset of new or progressive pulmonary symptoms, such as dyspnea, cough or fever within 4 weeks prior to first study treatment, or diagnosis of interstitial lung disease (ILD)
Exclusion for the Multiple Myeloma Exploratory Cohort
Women who are breast-feeding, pregnant, or intend to become pregnant.

Where it is running

Investigational Site 2 — Scottsdale, Arizona, United States
Investigational Site 3 — Columbus, Ohio, United States
Investigational Site 1 — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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