Treatment of Acetaminophen Toxicity With N-acetylcysteine

Completed

Conditions studied: Acetaminophen Toxicity

In brief

Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.

Key facts

Study ID

NCT00725179

Run by

Akron Children's Hospital

People needed

130

Starts

2008-08-01

Expected to finish

2008-10-01

Last updated by the study team

2011-09-09

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to CHMCA between June 1, 2004 to May 31, 2008 with a qualifying ICD-9 diagnosis code for the following APAP overdose situations; poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0)
• Serum APAP concentrations ≥ 150 g/mL at 4 hours or a serum concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained > 4 hours post ingestion
• Between the ages of 0-21 years

You may not qualify if…

• Serum APAP concentrations are not actually documented
• Patient did not receive oral or IV NAC treatment
• Patient has a preexisting liver disease such as cirrhosis or hepatitis C
• Patient > 21 years of age

Where it is running

• Children's Hospital Medical Center of Akron — Akron, Ohio, United States

Full record on ClinicalTrials.gov

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