Comparison of CT Angiography With Conventional Angiography and Intravascular Ultrasound in Heart Transplant Patients

Completed

Conditions studied: Heart Transplantation, Coronary Artery Disease

In brief

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for transplant coronary artery disease in the setting of heart transplant. Our current protocol at UCSF for heart transplant patients involves screening with stress tests as well as coronary angiograms with intravascular ultrasound to assess the diameter of the lumen of the coronary arteries and to assess wall thickness.

Key facts

Study ID

NCT00723281

Run by

University of California, San Francisco

People needed

18

Starts

2007-01-01

Expected to finish

2013-04-01

Last updated by the study team

2019-06-17

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient referred for coronary angiography and IVUS as part of their standard clinical care;
• Patients must be 18 years of age or older.
• Any ethnic background is acceptable.

You may not qualify if…

• Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
• Patients with heart rate higher than 65 bpm and contraindications for the use of beta-blockers, listed below:
• Systolic blood pressure < 90mmHg Decompensated congestive heart failure; COPD or asthma in use of bronchodilator; Second or third degree heart block; Severe aortic stenosis, defined by a pressure gradient higher than 50 mmHg and/or the presence of symptoms.
• Patients with contraindications for the use of nitroglycerin, listed below:
• Severe anemia; Increased intracranial pressure; Known hypersensitivity; Use of Sildenafil Citrate (Viagra®)
• Children and pregnant women will be excluded because of risks associated with radiation exposure.
• Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
• Patients unable to give informed consent will be excluded as well.
• Patients with a coronary stent placed.

Where it is running

• UCSF Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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