Open-Label, Chronic Exposure, Safety Study of CLONICEL (Clonidine HCl Sustained Release) in Children and Adolescents With Attention Deficit Hyperactivity Disorder (ADHD)

Completed · Phase 3

Conditions studied: Attention Deficit Hyperactivity Disorder

In brief

The purpose of this 12-month, multi-center, open-label study is to evaluate the safety of CLONICEL (clonidine HCl sustained release) when administered chronically under regular clinical conditions either as monotherapy or in combination with stimulant therapy to children and adolescents with attention deficit hyperactivity disorder (ADHD).

Key facts

Study ID

NCT00723190

Run by

Shionogi

People needed

303

Starts

2008-01-01

Expected to finish

2010-06-01

Last updated by the study team

2018-04-18

Who can join

Age: 6 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subject who has completed either study CLON-301 or study CLON-302, or discontinued early for reasons other than adverse events necessitating discontinuation
• Age between 6 and 17 years, inclusive
• Diagnosis of attention deficit hyperactivity disorder of the hyperactive or combined inattentive/hyperactive subtypes according to Diagnostic and Statistical Manual of Mental Disorders IV (DSM IV) criteria
• General good health as judged by the Principal Investigator
• Body mass index (BMI) ≥ 5th percentile of the subject's age group according to the CDC growth chart. BMI is calculated using the formula: weight (kg) / [height (m)]2
• Subject as well as parent/guardian able to sign informed assent or consent form

You may not qualify if…

• If female of child-bearing potential, pregnant or lactating or does not agree to use a medically acceptable form of birth control, such as hormonal medication, double-barrier method, or intrauterine device
• Presence of a clinically significant illness or abnormality on physical examination or clinical laboratory evaluations that, in the opinion of the investigator, would increase the safety risks from clonidine administration or interfere with the ability of the patient to take part in the study.
• Presence of clinically significant abnormality on centrally interpreted electrocardiogram readings
• History or presence of a concomitant psychiatric disorder requiring psychotropic medication or a severe concomitant axis I or axis II disorder that could interfere with study assessments in the judgment of the Principal Investigator
• Presence of a disorder that would interfere with the absorption, metabolism, or excretion of clonidine
• Presence of alcohol or drug abuse.

Where it is running

• Study site — Little Rock, Arkansas, United States
• Study site — El Centro, California, United States
• Study site — Irvine, California, United States
• Study site — San Diego, California, United States
• Study site — Bradenton, Florida, United States
• Study site — Gainesville, Florida, United States
• Study site — Jacksonville, Florida, United States
• Study site — Lauderhill, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Orlando, Florida, United States
• Study site — Bardstown, Kentucky, United States
• Study site — Baltimore, Maryland, United States
• Study site — Rochester Hills, Michigan, United States
• Study site — St Louis, Missouri, United States
• Study site — Voorhees Township, New Jersey, United States
• Study site — Willingboro, New Jersey, United States
• Study site — Chapel Hill, North Carolina, United States
• Study site — Charlotte, North Carolina, United States
• Study site — Durham, North Carolina, United States
• Study site — Cleveland, Ohio, United States
• Study site — Oklahoma City, Oklahoma, United States
• Study site — Oklahoma City, Oklahoma, United States
• Study site — Houston, Texas, United States
• Study site — Lake Jackson, Texas, United States
• Study site — Wharton, Texas, United States

Full record on ClinicalTrials.gov

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