Skeletal Muscle Properties and the Metabolic Cost of Walking Post-stroke
Completed
Conditions studied: Stroke
In brief
Of the \~700,000 persons who suffer a stroke each year, only 50% recover the ability to perform unlimited community walking. One mechanism contributing to locomotor dysfunction post-stroke is an increased metabolic cost of walking relative to neurologically healthy individuals 2-4. This increased cost likely limits the amount of walking performed, which further reduces functional capacity, thus contributing to long-term spiral of disability and decreased quality of life in these persons. In addition to increased metabolic cost, increased estimates of mechanical work are also characteristic of hemiparetic walking 2,29. Interestingly, although estimates of mechanical work reflect work done by locomotor muscles, little is known about the impact that peripheral muscle properties have on estimates of mechanical work. Furthermore, questions concerning how these properties relate to the increased metabolic cost of walking remain unanswered. The short-term objective and purpose of the proposed research is to determine the extent to which peripheral muscle characteristics, as well as estimates of muscle mechanical energy expenditure (MMEE), relate to the metabolic cost of walking post-stroke.
Key facts
- Study ID
- NCT00721357
- Run by
- VA Office of Research and Development
- People needed
- 30
- Starts
- 2008-08-01
- Expected to finish
- 2013-09-01
- Last updated by the study team
- 2019-03-18
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age 18-80;
- stroke within past 6 months - 5 years;
- residual paresis in the lower extremity (LE) (Fugl-Meyer motor score <34);
- ability to sit unsupported for 30 sec;
- ability to walk at least 10 ft with maximum 1 person assist;
- self selected 10 meter gait speed < 0.8 m/s; and
- provision of informed consent.
You may not qualify if…
- Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking < 200 meters;
- history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during activities of daily living;
- History of chronic obstructive pulmonary disease or oxygen dependence;
- Preexisting neurological disorders, dementia or previous stroke;
- History of major head trauma;
- Legal blindness or severe visual impairment;
- history of significant psychiatric illness;
- Life expectancy <1 yr;
- Severe arthritis or orthopedic problems that limit passive range of motion (ROM);
- post-stroke depression (PHQ-9 10);
- History of deep vein thrombosis (DVT) or pulmonary embolism within 6 months;
- Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions;
- Severe hypertension with systolic >200 mmHg and diastolic >110 mmHg at rest;
- Previous or current enrollment in a clinical trial to enhance motor recovery;
- Presence of non-magnetic resonance (MR) compatible implants or devices, pregnancy or severe claustrophobia.
Where it is running
- Ralph H. Johnson VA Medical Center, Charleston, SC — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
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