Lidocaine and Ketamine in Abdominal Surgery

Stopped early · Not applicable · Has a placebo group

Conditions studied: Abdominal Hysterectomy (& Wertheim)

In brief

This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

Key facts

Study ID

NCT00721110

Run by

The Cleveland Clinic

People needed

64

Starts

2008-07-01

Expected to finish

2012-07-01

Last updated by the study team

2017-07-26

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18 years old and less than 75 years years old
• Horizontal abdominal incision

You may not qualify if…

• Emergency or urgent procedure
• Preexisting chronic pain (at any site) requiring treatment
• Contraindication to any study medication (ketamine or lidocaine)
• History of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.)
• Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2 mg/dl) impairment
• Seizure disorder requiring medication within past 2 years
• Planned spinal or epidural anesthesia or analgesia

Where it is running

• Cleveland Clinic/Hillcrest Hospital — Mayfield Heights, Ohio, United States

Full record on ClinicalTrials.gov

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