Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
Completed · Phase 2
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving bevacizumab together with erlotinib may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with erlotinib works after radiation therapy and temozolomide in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.
Key facts
- Study ID
- NCT00720356
- Run by
- Northwestern University
- People needed
- 115
- Starts
- 2009-07-07
- Expected to finish
- 2018-07-05
- Last updated by the study team
- 2018-10-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
- M.D. Anderson Cancer Center at Orlando — Orlando, Florida, United States
- Northwestern University, Northwestern Medical Faculty Foundation — Chicago, Illinois, United States
- Evanston Hospital — Evanston, Illinois, United States
- Hollings Cancer Center at Medical University of South Carolina — Charleston, South Carolina, United States
- Neuro-Oncology Associates at Baylor University Medical Center, Dallas — Dallas, Texas, United States
- M.D. Anderson Cancer Center at University of Texas — Houston, Texas, United States
- The Methodist Hospital Neurological Institute — Houston, Texas, United States
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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