Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain

Stopped early · Not applicable · Has a placebo group

Conditions studied: Pain, Nausea

In brief

The investigators are conducting this study to find out if intravenous (injected through the vein) infusion of lidocaine and ketamine administered with general anesthesia is as effective as a paravertebral block in lessening pain after surgery and that both of these techniques are superior to general anesthesia alone in reducing pain immediately after surgery and in the long-term.

Key facts

Study ID

NCT00720330

Run by

The Cleveland Clinic

People needed

12

Starts

2008-07-01

Expected to finish

2010-02-01

Last updated by the study team

2019-03-12

Who can join

Age: 18 and older, up to 75. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than 18 and less than 75 years
• Male
• Unilateral inguinal hernia scheduled for elective open repair

You may not qualify if…

• Incarcerated hernia or urgent procedure
• Reoperation (recurrent hernia)
• Contraindication to regional anesthesia such as:
• Coagulopathy
• Infection at the site of needle insertion
• Pre-existing chronic pain (at any site) requiring treatment
• Contraindication to any study medication (local anesthetic or ketamine)
• History of significant Axis I psychiatric disease (major depressive disorder,bipolar disorder, schizophrenia, etc.)
• Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2 mg/dl) impairment

Where it is running

• Cleveland Clinic/Hillcrest Hospital — Mayfield Heights, Ohio, United States

Full record on ClinicalTrials.gov

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