Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

Completed

Conditions studied: Preeclampsia

In brief

The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly understood pathophysiology of preeclampsia. In this study we will compare the maternal plasma proteomes of early-onset severe preeclampsia versus healthy controls, compare protein expression and quantification of the maternal plasma proteome at the time of diagnosis of EOS-preeclampsia to the plasma proteome of the same affected subject at 48 hours post delivery and we will verify the placental expression of differentially expressed or post-translationally modified proteins found in the plasma of women with EOS-preeclampsia.

Key facts

Study ID

NCT00719654

Run by

Medical University of South Carolina

People needed

316

Starts

2007-08-01

Expected to finish

2012-04-09

Last updated by the study team

2018-05-18

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 20-34 weeks completed gestational age

You may not qualify if…

• Multiple gestation
• Chronic hypertension
• Diabetes
• Lupus
• Tobacco Use

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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