Pharmacokinetics and Pharmacdynamics of Sildenafil

Stopped early

Conditions studied: Pulmonary Hypertension

In brief

The study is being done to investigate what happens to sildenafil in the body and how long it takes to get rid of this drug. Understanding how long the drug stays in the body and how it is changed by the body will help doctors determine the best dose. We also want to learn how well the medicine works based on the size of the dose or amount in the bloodstream.

Key facts

Study ID

NCT00718185

Run by

Children's Hospital of Philadelphia

People needed

9

Starts

2008-05-01

Expected to finish

2010-02-01

Last updated by the study team

2015-03-12

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Receive enteral sildenafil as standard of care
• > 28 days to >18 years of age
• Informed consent/assent

You may not qualify if…

• Parents/guardians and/or subjects who, in the opinion of the investigator, may be noncompliant with study schedules or procedures.

Where it is running

• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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