Bacteriuria Eradication Through Probiotics

Status unconfirmed · Phase 1

Conditions studied: Bacteriuria

In brief

Many children who catheterize their bladders because of spina bifida or other neurologic disorders have bacteriuria. This can lead to urinary tract infections by bacteria from the gut which colonize the vagina and are carried into the bladder during catheter passage. We seek to test whether oral administration of probiotic bacteria can "displace" these vagina-derived uropathogens and reduce or prevent bacteriuria in girls with spina bifida who empty their bladders through catheterization.

Key facts

Study ID

NCT00717600

Run by

Baylor College of Medicine

People needed

10

Starts

2008-01-01

Expected to finish

2008-09-01

Last updated by the study team

2008-07-17

Who can join

Age: any, up to 18. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Eligible subjects are girls (age 3 months to 18 years) with spina bifida as a sole urologic diagnosis
• perform clean intermittent catheterization because of neurogenic bladder.
• Secondary vesicoureteral reflux is permissible.
• Patients with appendicovesicostomies and no other forms of urinary diversion are permitted.

You may not qualify if…

• Patients will be excluded if they are taking antibiotics
• immunosuppressed, i.e., transplant recipients or children with congenital immunodeficiencies
• poorly controlled diabetes
• untreated HIV infection
• immunosuppression from corticosteroids
• malnutrition
• pregnancy
• chronic indwelling catheters in the bladder
• any urinary diversion or bladder augmentation.

Where it is running

• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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