S-100B as Pre-Head CT Scan Screening Test After Mild Traumatic Brain Injury

Completed

Conditions studied: Traumatic Brain Injury

In brief

The purpose of the study is to determine if a specific blood protein, S-100B, can help predict who will have a traumatic abnormality on head CT scan after a concussion. We will compare the levels of this protein in the subject's blood to the initial head CT scan and to how the subject is feeling one month after injury. We hope that the information we collect in this trial will help us determine who needs a head CT scan after a concussion and who may be more likely to have trouble recovering from a concussion.

Key facts

Study ID

NCT00717301

Run by

University of Rochester

People needed

1252

Starts

2008-09-01

Expected to finish

2010-09-01

Last updated by the study team

2015-06-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting with head trauma to any of the AHCC/ERNES EDs, meeting the following criteria will be eligible to participate:
• Presence of mild TBI per study definition
• Arrival at the ED within 4 hours of injury
• ED workup includes a Head CT
• (Controls are eligible if they present to the Outpatient Lab for routine bloodwork during enrollment hours)

You may not qualify if…

• Time of injury not able to be determined
• Head CT not done as part of clinical emergency care
• Incarcerated
• Non-English or Spanish speakers
• Absence of parent/guardian for minor subjects
• Subject and/or parent/guardian do not have capacity to consent
• Head injury due to birth trauma, anoxia, inflammatory, toxic, infectious or metabolic encephalopathies that are not complications of head trauma
• Ischemic or hemorrhagic stroke without associated trauma
• (Controls are excluded if they have any of the following:History of brain tumor, melanoma and/or Alzheimer's disease; History of concussion, bone fracture or stroke (CVA or TIA) in the past month; History of surgery in the past month; Inability to obtain consent from subject and/or parent due to lack of capacity or absence of parent/guardian of minor; Inability to speak or read English; Incarceration)

Where it is running

• Albany Medical College — Albany, New York, United States
• Erie County Medical Center — Buffalo, New York, United States
• Bassett Healthcare — Cooperstown, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• SUNY Upstate Medical Center at Syracuse — Syracuse, New York, United States
• Guthrie — Sayre, Pennsylvania, United States

Full record on ClinicalTrials.gov

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