Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
Completed · Phase 3
Conditions studied: Brain Tumor, Central Nervous System Tumor, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Liver Cancer, Neuroblastoma, Ototoxicity, Ovarian Cancer, Sarcoma
In brief
RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing hearing loss. PURPOSE: This randomized phase III trial is studying sodium thiosulfate to see how well it works in preventing hearing loss in young patients receiving cisplatin for newly diagnosed germ cell tumor, hepatoblastoma, medulloblastoma, neuroblastoma, osteosarcoma, or other malignancy.
Key facts
- Study ID
- NCT00716976
- Run by
- Children's Oncology Group
- People needed
- 131
- Starts
- 2008-06-23
- Expected to finish
- 2021-06-30
- Last updated by the study team
- 2023-11-09
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Childrens Hospital Los Angeles — Los Angeles, California, United States
- Southern California Permanente Medical Group — Los Angeles, California, United States
- Children's Hospital Central California — Madera, California, United States
- Rady Children's Hospital - San Diego — San Diego, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Connecticut Children's Medical Center — Hartford, Connecticut, United States
- Yale Cancer Center — New Haven, Connecticut, United States
- Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- University of Miami Sylvester Comprehensive Cancer Center - Miami — Miami, Florida, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- Nemours Children's Clinic - Orlando — Orlando, Florida, United States
- Nemours Children's Clinic - Pensacola — Pensacola, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
- Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
- Mountain States Tumor Institute at St. Luke's Regional Medical Center — Boise, Idaho, United States
- University of Illinois Cancer Center — Chicago, Illinois, United States
- Saint Jude Midwest Affiliate — Peoria, Illinois, United States
- Riley's Children Cancer Center at Riley Hospital for Children — Indianapolis, Indiana, United States
- Blank Children's Hospital — Des Moines, Iowa, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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