Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Completed · Phase 2/Phase 3
Conditions studied: Atelectasis
In brief
The purpose of this study is to determine whether breathing high levels of oxygen during surgery affects oxygen levels after surgery. The second purpose of this study is to determine whether giving positive end expiratory pressure PEEP and high oxygen together affects patients oxygen levels after surgery.
Key facts
- Study ID
- NCT00715741
- Run by
- University of Utah
- People needed
- 100
- Starts
- 2008-06-01
- Expected to finish
- 2009-07-01
- Last updated by the study team
- 2010-02-18
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 18-70 years undergoing surgery under general endotracheal anesthesia at the University of Utah Hospital Operating Room and the Huntsman Cancer Hospital Operating room who will be admitted to the hospital for at least 24 hours after surgery
You may not qualify if…
- Major (open) abdominal surgery
- Major spine surgery
- Craniotomy surgery
- Surgeries where electrocautery or laser devices may be used near the airway (eg tracheostomy, oral surgery) because of the risk of fire with high inspired oxygen in these cases
- Procedures planned for monitored anesthesia care (MAC) or regional without general anesthesia
- Planned airway management with a laryngeal mask airway rather than an endotracheal tube
- Procedures planned in the prone position because this increases atelectasis
- Planned postoperative intubation
- Planned postoperative care in the intensive care unit
- Recent (within 3 weeks) chemotherapy because of the increased risk of pulmonary oxygen toxicity
- History of bleomycin administration because of the increased risk of pulmonary oxygen toxicity
- Diagnosed Obstructive Sleep Apnea with home continuous pulmonary airway pressure (CPAP) use
- Home oxygen use
- Preoperative room air (RA) SpO2 <90%
- History of spontaneous pneumothorax
- Emergency surgery
- Pregnancy. Women of child-bearing age are routinely screened for pregnancy urine human chorionic gonadotropin, (HCG) on the morning of surgery. Patients with a positive result will be excluded from the study (and most likely will have their elective surgery cancelled).
- Patient refusal
Where it is running
- University of Utah Health Sciences Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.