Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication

Completed · Phase 4 · Has a placebo group

Conditions studied: Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis

In brief

Atherosclerosis is a condition that occurs when fatty deposits build up along the inner walls of arteries. This study will examine the effectiveness of a combination of cholesterol-lowering medications at decreasing the fat content of atherosclerotic deposits in people who have coronary artery disease or carotid artery disease.

Key facts

Study ID

NCT00715273

Run by

University of Washington

People needed

217

Starts

2001-05-01

Expected to finish

2019-03-01

Last updated by the study team

2022-06-07

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically established coronary artery disease or carotid artery disease with greater than 15% stenosis by ultrasound
• Family history of cardiovascular disease
• Apolipoprotein B level greater than or equal to 120 mg/dL (LDL level should be between 100 and 190 mg/dL without medication)
• Has been undergoing lipid therapy for no more than 12 months before study entry
• Medically stable
• Medically able to undergo MRI procedure

You may not qualify if…

• Uses pacemaker or has metallic implants
• Has immediate plans for carotid endarterectomy
• History of alcohol or drug abuse
• Active liver disease or liver dysfunction, defined by elevations in alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels greater than 1.5 times the upper limit of normal
• Serum creatine kinase (CK) level greater than 3 times the upper limit of normal before study entry
• Serum creatinine level greater than 2.5 times the upper limit of normal
• Diabetes, with a fasting glucose level greater than 150 mg/dL or hemoglobin A1c (HbA1c) level greater than 8% before study entry
• Uncontrolled high blood pressure, defined as average resting systolic blood pressure greater than 200 mm Hg or average resting diastolic blood pressure greater than 95 mm Hg

Where it is running

• University of Southern California — Los Angeles, California, United States
• St. Luke's Idaho Cardiology — Boise, Idaho, United States
• University of Washington Coronary Atherosclerosis Research Lab — Seattle, Washington, United States
• Yakima Heart Center — Yakima, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.