Polycythemia Vera, Myelofibrosis and Essential Thrombocythemia: Identification of PV, MF & ET Genes
Completed
Conditions studied: Polycythemia Vera, Essential Thrombocythemia, Myelofibrosis
In brief
The purpose of this project is to find genes whose mutations cause Polycythemia Vera, Essential Thrombocythemia and Primary Myelofibrosis.
Key facts
- Study ID
- NCT00715247
- Run by
- University of Utah
- People needed
- 726
- Starts
- 2006-07-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2019-10-15
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients with an elevated hemoglobin concentration (>18 in males and >16 in females) and who are suspected to have congenital or acquired primary polycythemia
- Patients with a persistent thrombocytosis (>400,000) that does not have an obvious secondary cause
- Patients with a bone marrow biopsy that shows increased cellularity and fibrosis
- Patients where there is clinical concern for primary myelofibrosis, such as anemia in combination with leukocytosis, thrombocytosis, splenomegaly and/or a leukoerythroblastic blood smear
- Patients with thrombosis at unusual sites, such as Budd-Chiari syndrome, can have early PV before hemoglobin is elevated, these patients will also be included.
You may not qualify if…
- Subjects who have a known acquired cause of polycythemia (increased hemoglobin/hematocrit) such as people living in high altitudes (in excess of 14,000 feet), subjects with heart disease, left to right heart shunt, severe hypoxia or severe pulmonary disease will be excluded from this study.
- Subjects with a known acquired cause of thrombocytosis.
- Subjects will be excluded if they cannot demonstrate decision making capacity sufficient to agree or decline the blood drawing or use of their blood for the study.
Where it is running
- University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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