Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

Completed

Conditions studied: Asthma, Exercise Induced

In brief

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Key facts

Study ID

NCT00710255

Run by

University of Vermont

People needed

8

Starts

2007-10-01

Expected to finish

2009-07-01

Last updated by the study team

2016-10-31

Who can join

Age: 12 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Physician diagnosed asthma
• Age 12-75 yrs
• FEV1 > 70% predicted
• HIB response > 10 %
• No smoking last 6 mo and < 10 pack yrs
• No URI last 4 weeks
• No asthma exacerbation last 4 weks
• Able to withhold SABA > 8 hrs and LABA > 24 hrs

You may not qualify if…

• Other lung disease
• Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Where it is running

• Vermont Lung Center — Colchester, Vermont, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.