Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors

Stopped early

Conditions studied: Primary Central Nervous System Lymphoma (PCNSL)

In brief

This research is being done to investigate cognition in long term survivors of Primary Central Nervous System Lymphoma (PCNSL). Sometimes caregivers as well as patients who no longer have the disease report cognitive problems such as reduced memory or attentional dysfunction and decreased quality of life. Unfortunately, little is known about what may contribute to this cognitive dysfunction in part because PCNSL is a rare disease and sensitive tests have not often been used in the research studies. This project is being conducted to help understand what factors, such as radiation, may contribute to cognitive dysfunction and better define the relationship between brain structure and thinking in people who have had PCNSL.

Key facts

Study ID: NCT00710151
Run by: OHSU Knight Cancer Institute
People needed: 80
Starts: 2008-07-01
Expected to finish: 2013-12-01
Last updated by the study team: 2017-04-21

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Radiological and histological diagnosis of PCNSL
Age 18 years or older
Survived 2 years or more following treatment
Able to complete neuropsychological and neuroimaging parts of the study
Signed a written informed consent in accordance with institutional guidelines

You may not qualify if…

Subject has experienced recurrent disease
Subject has a contraindication for MRI
Subject has a contraindication for neuropsychological testing
Subject has stage IV or V renal insufficiency

Where it is running

Oregon Health & Science University — Portland, Oregon, United States
Charite University Medicine — Berlin, Germany
University of Bochum — Bochum, Germany
University Medical Center — Freiburg im Breisgau, Germany

Full record on ClinicalTrials.gov

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