Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

Recruiting now

Conditions studied: Chronic Lung Disease

In brief

The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.

Key facts

Study ID

NCT00710112

Run by

Medical College of Wisconsin

People needed

1100

Starts

2006-06-01

Expected to finish

2028-06-01

Last updated by the study team

2026-01-26

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants born weighing less than 1500 grams

You may not qualify if…

• Infants born with congenital heart disease (other than patent ductus arteriosus)
• major congenital anomalies of the GI tract, respiratory tract, or kidneys

Where it is running

• Children's Wisconsin — Milwaukee, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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