Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness

Completed · Not applicable · Has a placebo group

Conditions studied: Intensive Care Unit, Muscle Weakness

In brief

The purpose of this study is to investigate whether neuromuscular electrostimulation (NMES) will decrease ICU-associated weakness. The investigators believe that 60 minutes of daily NMES will improve strength and function in those who have had extended ICU stays, as well as decrease critical illness myopathy as an etiology of weakness in the critically ill.

Key facts

Study ID

NCT00709124

Run by

Johns Hopkins University

People needed

36

Starts

2008-06-01

Expected to finish

2013-04-01

Last updated by the study team

2018-01-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1 day of mechanical ventilation with an expectation of requiring ≥2 additional days of ICU stay in a Johns Hopkins Intensive Care Unit (ICU)

You may not qualify if…

• Unable to understand or speak English due to language barrier or cognitive impairment prior to admission
• Unable to independently transfer from bed to chair at baseline prior to hospital admission
• Known primary systemic neuromuscular disease (e.g. Guillian-Barre) at ICU admission
• Known intracranial process that is associated with localizing weakness (e.g. cerebral vascular accident) at ICU admission
• Transferred from another ICU outside of the Johns Hopkins system after >4 consecutive days of mechanical ventilation
• Moribund (i.e. >90% probability of patient mortality in the next 96 hours)
• Anticipated transfer to another ICU for care (e.g. awaiting organ transplantation and transfer to surgical ICU)
• Any pacemaker (e.g., cardiac, diaphragm) or implanted cardiac defibrillator
• Pregnancy
• Body mass index ≥35 kg/m2
• Any limitation in life support other than a sole no-CPR order
• Known or suspected malignancy in the legs
• Unable to treat or evaluate both lower extremities (e.g., bilateral amputation, bilateral skin lesions)
• ICU length of stay >7 days prior to enrollment

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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