Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude

Status unconfirmed · Phase 1

Conditions studied: Hypoxic Pulmonary Vasoconstriction

In brief

The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during exercise at high altitude.

Key facts

Study ID

NCT00708565

Run by

VA Loma Linda Health Care System

People needed

50

Starts

2008-07-01

Expected to finish

2008-10-01

Last updated by the study team

2008-07-02

Who can join

Age: 18 and older, up to 80. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Age: 18 - 80 years
• Healthy physically active males or females
• Have readily measurable tricuspid regurgitation (TR) peak systolic velocity by continuous wave Doppler ultrasound

You may not qualify if…

• Unable to measure TR velocity
• Known liver disease
• Pregnancy
• Nitrates, cyclosporin, glyburide or other medications that in the opinion of the investigators could place subjects at increased risk of complications
• Any other medical condition that in the opinion of the investigators would place the subject at high risk

Where it is running

• Jerry L. Pettis VA Medical Center — Loma Linda, California, United States (enrolling)

Full record on ClinicalTrials.gov

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