Live Births With Low Oxygen Blastocyst Culture

Completed · Not applicable

Conditions studied: Infertility, Pregnancy Rate, Live Birth, In Vitro Fertilization

In brief

The potentially damaging effect of free O2 radicals to cultured embryos may be reduced by adding scavengers to the culture media or by reducing the incubator O2 levels. However, lowering the O2 in the culture environment can be expensive, troublesome and may not be justifiable. The objective of this study is to evaluate the effect of lowered incubator O2 tension on live birth rates in a predominately day-5 embryo transfer program. The hypothesis of this study is that a lowered (more physiological)oxygen concentration in embryo culture incubators will increase live birth rates for in vitro fertilization patients. 230 first-cycle women undergoing routine IVF or ICSI with ejaculated sperm will be randomized in a prospective clinical trial and stratified for patient age and physician. Embryos of patients will be randomly assigned for culture in either a 21% O2 (atmospheric) or 5% O2 (reduced) environment. Clinical endpoints monitored will be rates of implantation, clinical pregnancy, live birth and blastocyst cryopreservation.

Key facts

Study ID

NCT00708487

Run by

Texas Health Resources

People needed

230

Starts

1999-08-01

Expected to finish

2001-08-01

Last updated by the study team

2008-07-02

Who can join

Age: 20 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• First IVF cycle or donor oocyte cycle
• IVF or ICSI
• Ejaculated sperm only for ICSI
• <41 years of age

You may not qualify if…

• One or more failed IVF cycles
• 40 years of age
• Using testicular or epididymal sperm for fertilization

Where it is running

• Presbyterian Hospital of Palno — Plano, Texas, United States

Full record on ClinicalTrials.gov

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