Common Genetic Variation and Type 2 Diabetes

Completed

Conditions studied: Pre-diabetes

In brief

Type 2 diabetes is a common metabolic disorder arising from a complex interaction between genetic predisposition and the environment. The development of this disorder is preceded by impaired glucose tolerance and elevated fasting glucose which also carry adverse cardiovascular risk. To date a few common genetic variants have been reliably associated with predisposition to type 2 diabetes. However, it is uncertain how these genes interact to alter insulin secretion and insulin action prior to the development of type 2 diabetes. We propose to utilize an established population-based cohort to determine how common genetic variants associated with type 2 diabetes alter the response to an oral glucose challenge in people without overt type 2 diabetes. This will enable us to understand how common variants alone or in combination alter whole-body glucose physiology and predispose to type 2 diabetes.

Key facts

Study ID

NCT00707616

Run by

Mayo Clinic

People needed

190

Starts

2006-03-01

Expected to finish

2012-12-01

Last updated by the study team

2013-01-23

Who can join

Age: 35 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Fasting blood glucose < 126mg/dL

You may not qualify if…

• Fasting blood glucose > 126mg/dL

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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