A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure

Completed

Conditions studied: Normal Tension Glaucoma

In brief

The objective of this study is to determine whether systemic blood pressure in the body is related to the development and progression of normal tension glaucoma in the eye. The study aims to clarify whether subjects with episodes of hypotension (low blood pressure) at night are at increased risk for sight loss and the development of normal tension glaucoma.

Key facts

Study ID

NCT00706056

Run by

Weill Medical College of Cornell University

People needed

85

Starts

2008-09-01

Expected to finish

2011-09-01

Last updated by the study team

2017-02-23

Who can join

Age: 21 and older, up to 101. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The IOP must be less than or equal to 21 mmHg without treatment and must have never been higher than 24 mmHg, without treatment.
• Gonioscopically open angles.
• Typical glaucomatous optic disc changes, including: rim thinning, cupping, rim notching, disc hemorrhage, nerve fiber layer defect, vertical cup/disc asymmetry ≥0.2.
• A reproducible visual field defect must have been demonstrated on at least three prior visual fields, as observed using standard automated perimetry with Swedish Interactive Threshold Algorithm (SITA-STANDARD) from the Humphrey Visual Field Analyzer using the 24-2 test pattern.
• There must have been progression of glaucomatous loss with the past 36 months, specifically, two or more adjacent non-peripheral points changed by 10dB relative to the average baseline value for the points, confirmed by two subsequent fields.

You may not qualify if…

• Subjects with a visual field defect attributable to conditions other than glaucoma, such as a history of intra-cranial or ENT mass lesion.
• Occludable narrow angles.
• Subjects with intermittent elevation of intraocular pressure associated with another form of glaucoma, including intermittent angle closure, inflammatory glaucoma, old pigmentary glaucoma, psedoexfoliation or uveitis.
• Subjects who cannot complete follow-up testing every six months for any reason.
• Subjects who are unable to provide informed consent or who refuse or whose physicians do not wish for the subjects to participate for any reason.

Where it is running

• Glaucoma Associates of New York/New York Eye and Ear Infirmary — New York, New York, United States
• The New York Presbyterian Hospital-Weill Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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