Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma

Completed · Phase 1

Conditions studied: Cancer

In brief

This study will aims to determine the maximum tolerated dose of CGC-11047 when used in individual combinations with gemcitabine, or docetaxel, or bevacizumab, or erlotinib or cisplatin or 5-flurouracil or sunitinib in one of 7 treatment arms. The dose of CGC-11047 will be escalated until the maximum tolerated dose is established.

Key facts

Study ID

NCT00705874

Run by

Progen Pharmaceuticals

People needed

172

Starts

2006-05-01

Expected to finish

2011-09-01

Last updated by the study team

2016-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• non-hematological advanced solid tumor malignancy or lymphoma where no curative therapy exists in which monotherapy with gemcitabine or docetaxel or bevacizumab or erlotinib or cisplatin, or 5-flurouracil or sunitinib would otherwise be warranted.
• measurable disease based on radiographic evaluation or elevated tumor markers.
• ECOG - 0 or 1 (KPS >70).
• Life expectancy > 3 months.

You may not qualify if…

• chemotherapy within 21 days or radiotherapy within 4 weeks prior to entering the study
• known active brain metastases or leptomeningeal carcinomatosis.
• history of a myocardial infarction within the prior 6 months or, hospitalizations for congestive heart failure within the prior 6 months, or active treatment for uncontrolled cardiac arrhythmias
• clinically significant gastrointestinal tract hemorrhage, requiring transfusion therapy, within the prior 3 months.

Where it is running

• Rocky Mountain Cancer Centre — Denver, Colorado, United States
• Cancer Centres of Florida — Ocoee, Florida, United States
• Central Indiana Cancer Centres — Indianapolis, Indiana, United States
• Comprehensive Cancer Centres of Nevada — Las Vegas, Nevada, United States
• New York Oncology Hematology PC — Albany, New York, United States
• Dayton Oncology and Hematology, PA — Kettering, Ohio, United States
• Cancer Centres of the Carolinas — Greenville, South Carolina, United States
• Texas Oncology, PA — Dallas, Texas, United States
• Tyler Cancer Centre — Tyler, Texas, United States
• Virginia Oncology Associates — Norfolk, Virginia, United States
• Northwest Cancer Specialists - Vancouver Cancer Centre — Vancouver, Washington, United States
• North Star Lodge Cancer Centre — Yakima, Washington, United States

Full record on ClinicalTrials.gov

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