Gene Expression Profiles in Multiple Sclerosis (MS)

Completed

Conditions studied: Multiple Sclerosis

In brief

The purpose of this study is to test differences in RNA levels between Multiple Sclerosis (MS) patients and normal subjects. RNA provides a "message" from genes altered in diseases. We will also test DNA to determine if there are any small mutations called SNPs in any of the genes. The last tests are two separate tests for markers of inflammation called cytokines and eicosanoids. This research may lead to the discovery of biological markers for MS that are useful for diagnosis and treatment.

Key facts

Study ID

NCT00704834

Run by

University of California, Davis

People needed

46

Starts

2006-03-01

Expected to finish

2017-07-05

Last updated by the study team

2020-02-21

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• males and females
• any race
• Between the ages of 18 and 70 years
• Diagnosed with a clinically isolated syndrome or the diagnosis of multiple sclerosis using the widely established Macdonald criteria. A 'clinically isolated syndrome' refers to an isolated attack of optic neuritis, transverse myelitis, or brain demyelination. Relapsing-remitting MS is characterized by acute relapses that are followed by some degree of recovery without worsening of disability between relapses. Chronic progressive MS is defined as sustained progression of physical disability, occurring separately from relapses, in patients with MS.
• Control subjects will be male or female, between the ages 18 to 70 years, of any race, with no symptoms of MS.

You may not qualify if…

• Children are excluded from the study because MS is generally a disease of young adult onset and is rare in children.
• Evidence of infection or communicable disease, cancer or other known systemic disease, anti-coagulation, known bleeding disorder, illicit drug abuse, or change in medications in the last 30 days (including treatment with steroids).
• Patients receiving any other immune modulating medications (steroids, cyclophosphamide, mitoxantrone, methotrexate, mycophenolate mofetil, azathioprine, IVIG or rituximab) in the prior thirty days will be excluded from the study

Where it is running

• University of California, Davis — Sacramento, California, United States

Full record on ClinicalTrials.gov

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