Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)

Completed · Phase 4

Conditions studied: Post-traumatic Stress Disorder

In brief

The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment.

Key facts

Study ID

NCT00700999

Run by

US Department of Veterans Affairs

People needed

65

Starts

2008-10-01

Expected to finish

2012-03-01

Last updated by the study team

2014-06-03

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veterans with clinical diagnosis of post-traumatic stress disorder from combat related to deployment to Afghanistan/Iraq (Operation Enduring Freedom/Operation Iraqi Freedom)

You may not qualify if…

• Intolerance or sensitivity to paroxetine
• Major medical or neurologic illness
• Current psychotropic medication or active psychotherapy treatment
• Other major psychiatric illness

Where it is running

• Jesse Brown VA Medical Center Community-Based Outpatient Clinic Lake Side Divison, Chicago, IL — Chicago, Illinois, United States
• Jesse Brown VA Medical Center, Chicago, IL — Chicago, Illinois, United States
• VA Ann Arbor Healthcare System, Ann Arbor, MI — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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