Lovastatin as a Potential Modulator of Apoptosis in Chronic Obstructive Pulmonary Disease (COPD)
Completed · Phase 2 · Has a placebo group
Conditions studied: Chronic Obstructive Pulmonary Disease (COPD)
In brief
This study will test whether lovastatin helps to modify lung inflammation in patients with COPD (Chronic Obstructive Pulmonary Disease).
Key facts
- Study ID
- NCT00700921
- Run by
- National Jewish Health
- People needed
- 30
- Starts
- 2008-04-01
- Expected to finish
- 2012-11-01
- Last updated by the study team
- 2021-01-19
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (≥45 years) former smokers with ≥ 10 pack-years of cigarette smoking
- FEV1/FVC ratio < 70%
- Post-bronchodilator FEV1 between 50% and 80% of predicted if undergoing bronchoscopy, or between 30% and 80% of predicted if undergoing induced sputum only
- DLco/VA < 80% predicted
- Ability to perform and adhere to study protocol
- ability to provide informed consent.
You may not qualify if…
- Asthma or other comorbid lung disease,
- Hypoxemia (PaO2 < 55 mmHg or SpO2 < 88% on room air), if undergoing bronchoscopy
- Exacerbation of COPD within the last 6 weeks
- Upper or lower respiratory tract infection within the last 6 weeks
- Current smoking
- Significant coronary artery disease as reflected by unstable angina, myocardial infarction or angioplasty/stenting/bypass surgery within 6 months
- Current use of HMG-coA-reductase inhibitors
- Current use of inhaled corticosteroid
- Concurrent use of other Cyp3A4 (isoform of cytochrome P450) inhibitors
- History of adverse reaction to HMG-coA-reductase inhibitors (rhabdomyolysis, hepatitis)
- For patients undergoing bronchoscopy, any contraindication to fiberoptic bronchoscopy or conscious sedation, including abnormalities of the platelet count, prothrombin time or partial thromboplastin time.
Where it is running
- National Jewish Medical and Research Center — Denver, Colorado, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.