Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Delirium

In brief

In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.

Key facts

Study ID

NCT00699946

Run by

The New England Baptist Hospital

People needed

495

Starts

2005-01-01

Expected to finish

2007-10-01

Last updated by the study team

2009-01-21

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• High risk for delirium age > 65 history of delirium medical comorbidities ability to give informed consent

You may not qualify if…

• Dementia Alcohol abuse Current use of an antipsychotic Allergy to olanzapine

Where it is running

• New England Baptist Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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