Effects of Nitrous Oxide on Intraocular Pressure

Stopped early

Conditions studied: Post Operative Visual Loss

In brief

The concept of ocular perfusion pressure (OPP), is defined as the difference between the mean arterial pressure (MAP) and the intraocular pressure (IOP.)It has been hypothesized that unopposed decreases in MAP, increases in IOP or a combination of the two may result in hypo perfusion of the eye and can cause an ocular infarction at the level of the retina or optic nerve, leading to varying degrees of visual loss which is frequently bilateral and irreversible. Both the prone position and downward head tilting (Trendelenburg position) have been associated with increases in IOP compared to the supine horizontal position (2,4,5,6), but it is not known whether the Trendelenburg position during surgery and anesthesia is associated with POVL.

Key facts

Study ID

NCT00696189

Run by

Rutgers, The State University of New Jersey

People needed

30

Starts

2006-09-01

Expected to finish

2011-09-01

Last updated by the study team

2015-04-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• If I am between the ages of 18 and 65 years of age and mentally capable of giving consent.
• If I am scheduled for gynecological surgery and will be placed in the Trendelenburg position (head lower than my waist) on the operating room table.

You may not qualify if…

• If I fail/refuse to provide an informed consent
• If I have a history of stroke or trans-ischemic attack (TIA).
• If I have a history of corneal disease.
• If I a have a sensitivity to eye drops called proparacaine
• If I have had a previous diagnosis of carotid disease.
• If I have a history of glaucoma
• If I am taking medications which may affect the pressure in my eyes

Where it is running

• UMDNJ — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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