Screening for Barrett's Esophagus in Otolaryngology Patients

Completed · Not applicable

Conditions studied: Extraesophageal Symptoms, Cough, Throat Clearing, Hoarseness, Difficulty Swallowing

In brief

The purpose of this project is to develop an accurate method to identify patients that suffer from acid reflux, but may not present with classic reflux symptoms (such as heart burn). Additionally, it is the purpose of this project to utilize the Unsedated Small-caliber Endoscopy (USE) to assess the prevalence of Barrett's esophagus in a population of patients with laryngopharyngeal reflux (LPR) symptoms and to define normal patterns of LPR. Laryngopharyngeal reflux (LPR) is when a small amount of stomach contents and acid are pushed up through the esophagus and may affect the vocal cords and upper respiratory tract. It is suspected that patients with LPR symptoms may have a prevalence of Barrett's esophagus similar to that found in a population with typical reflux symptoms. We propose to systematically test this hypothesis using the USE. This project is designed to improve the methods of identifying patients with a form of acid reflux that is often undetected, and thus untreated. If this project is successful then more patients with Barrett's esophagus will be identified; furthermore, screening and treatment for this pre-cancerous condition will be improved.

Key facts

Study ID
NCT00695227
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
People needed
295
Starts
2004-05-01
Expected to finish
2011-12-01
Last updated by the study team
2018-03-06

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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