Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis
Completed
Conditions studied: Myocarditis
In brief
Children can have or develop certain problems with their heart function, specifically with the heart muscle or myocardium. This problem can be caused by many things specifically by infection resulting in myocarditis (inflammation of the heart muscle) or dilated cardiomyopathy (caused by many factors including high blood pressure and heart attacks). The body goes through many processes to repair the injured tissue including using proteins that cause the muscle mass to increase called matrix metalloproteinases (MMPs). The body also uses proteins that direct the MMPs to stop increasing the muscle mass called tissue inhibitory of metalloproteinases (TIMPs). Currently, there are no published studies that explain or evaluate the relationship that MMPs and TIMPs have in myocarditis and dilated cardiomyopathy in children. The investigator wishes to perform a prospective study of the serum levels of these proteins and their regulators in children with myocarditis and/or dilated cardiomyopathy and compare them with children that have no heart disease.
Key facts
- Study ID
- NCT00693134
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 36
- Starts
- 2004-03-01
- Expected to finish
- 2006-07-01
- Last updated by the study team
- 2008-06-06
Who can join
Age: 0 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Evidence from diagnostic tests and physical exam that confirm inflammatory cardiomyopathy.
You may not qualify if…
- Patients with structural heart disease other than septal defects or patent ductus arteriosus
- Patients with history of arrhythmia
- Patients with history of ventricular dysfunction diagnosed by echocardiograms
- Patients with history of chronic systemic illness
Where it is running
- Children's Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.