Autoimmunity in Neurologic Complications of Celiac Disease
Completed
Conditions studied: Ataxia
In brief
This study, done in collaboration with Cornell University in New York, will explore the potential role of the body s immune response to gluten in ataxia. Celiac disease is an autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. Some people with celiac disease also develop ataxia, which is a loss of muscle coordination, leading to imbalance. The cause of the associated ataxia is not well understood, but it is suspected to be related to the immune response towards gluten in these patients. Preliminary results indicate that antibodies in people with celiac disease can react with brain proteins, which might have a role in the associated neurologic deficits. The aim of this study is to characterize the immune response in the ataxia that is associated with celiac disease. People 18 years of age and older with 1) ataxia and no celiac disease, 2) ataxia plus celiac disease and 3) matched healthy control subjects will be enrolled at the NIH. People with celiac disease only will be enrolled at Cornell University. All participants have a blood sample drawn for various tests of immune function as well as genetic tests. Healthy volunteers also have a history and physical examination if they have not had one done at NIH in the past year. Some patients may require additional clinical evaluations for clinical or diagnostic reasons.
Key facts
- Study ID
- NCT00692861
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 14
- Starts
- 2008-06-02
- Expected to finish
- 2014-01-03
- Last updated by the study team
- 2019-12-16
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- For all groups, if other neurological and psychiatric diagnoses are present, the individual will not qualify to participate in this study.
- EXCLUSION CRITERIA FOR ALL GROUPS:
- Subject is already on a gluten-restricted diet.
- Is taking known immune modulating therapy
- Have other neurological condition (except for neuropathy) or psychiatric condition
- Not willing to have blood drawn
- Is known to have immune dysfunction
- Being pregnant leads to numerous physiological changes. It is unclear if antibody characteristics are influenced by these changes.
Where it is running
- Cornell University — New York, New York, United States
Full record on ClinicalTrials.gov
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