Effectiveness of Olanzapine Versus Placebo in Treating Outpatients With Anorexia Nervosa
Completed · Phase 2 · Has a placebo group
Conditions studied: Eating Disorders
In brief
This study will evaluate the effectiveness of the antipsychotic medication olanzapine in treating outpatients with anorexia nervosa.
Key facts
- Study ID
- NCT00692185
- Run by
- New York State Psychiatric Institute
- People needed
- 23
- Starts
- 2005-10-01
- Expected to finish
- 2010-09-01
- Last updated by the study team
- 2019-05-10
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meets DSM-IV criteria (not including amenorrhea) for AN
- Body mass index (BMI) less than 19 kg/m2 and greater than 14 kg/m2
- Patient (or family if the patient is a minor) refuses hospitalization
- Free of psychotropic medication (4 weeks medication free for fluoxetine and antipsychotic medication; 2 weeks medication free for all others) OR on a stable dose of an SSRI or SNRI (venlafaxine) for 4 weeks before study entry
- Prior treatment of AN
You may not qualify if…
- Any medical or psychiatric problem requiring urgent attention and/or any significant comorbid illness not likely to benefit from proposed treatments
- Allergy to olanzapine
- Significant orthostatic high blood pressure
- Recent commencement of psychotherapy in the community
- Diabetes mellitus, with a fasting serum glucose greater than 120 mg/dL or nonfasting serum glucose greater than 140 mg/dL
- Known history of current or past jaundice
- Known history of narrow angle glaucoma
- Active substance abuse or dependence
- Schizophrenia, schizophreniform disorder, or bipolar illness
- Movement disorder or presence of tics
- History of tardive dyskinesia
- History of seizures
- Pregnant
Where it is running
- Eating Disorders Clinic, New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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