Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis

Completed · Phase 4

Conditions studied: Atopic Dermatitis

In brief

The purpose of this research study is to better understand how this study drug works when people use it to treat atopic dermatitis. Desonate has been approved by the US Food and Drug Administration (FDA) for atopic dermatitis.

Key facts

Study ID

NCT00690833

Run by

Wake Forest University

People needed

41

Starts

2007-08-01

Expected to finish

2009-11-01

Last updated by the study team

2018-09-10

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age 3 months or greater.
• Subjects must have diagnosis of mild to moderate atopic dermatitis by an investigator (a 2 or 3 on the IGA scale).
• Subjects must have >2% BSA involvement to be enrolled.
• Informed consent of participation must be given by parent or guardian if he or she is <7 years old. Children who are 7 to 18 years old will be given an assent form to sign.
• Moisturizers will be allowed during the study as long as the use remains stable from screening/baseline throughout the study.

You may not qualify if…

• Known allergy or sensitivity to topical desonide hydrogel in the subject.
• Inability to complete all study-related visits.
• Introduction of any other prescription medication, topical or systemic, for atopic dermatitis while participating in the study. Other than stable use of over the counter non-medicated moisturizers, all other topical treatments for AD must be stopped prior to study drug initiation. There will be no required washout for any topical therapies. Stable use of systemic therapies may be continued throughout the study.
• Requiring >130 gm of cream in a 4 week period.
• Pregnant women and women who are breastfeeding are to be excluded. Women of childbearing potential will be allowed to participate in the study, and these subjects will be required to use at least one form of birth control. Use of desonide in pregnant subjects is controversial and is only to be used when benefits outweigh the risks.

Where it is running

• Wake Forest University Health Sciences Dermatology — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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