Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome

Completed

Conditions studied: Diabetes Mellitus, Type 2

In brief

The investigators are examining the activation of insulin signaling factors in skeletal muscles of human diabetics. The investigators are characterizing the defects in signaling, and are examining the effects of anti-diabetic agents and exercise on signaling to glucose transport biochemical machinery and whole body glucose disposal.

Key facts

Study ID

NCT00690755

Run by

VA Office of Research and Development

People needed

157

Starts

2000-05-01

Expected to finish

2012-09-01

Last updated by the study team

2016-05-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Stable uncomplicated type 2 diabetes
• Able to be off oral treatments for 2 months

You may not qualify if…

• Diabetic complications related to heart, eye, nerve problems
• Renal impairment
• Cardiovascular disease
• Hepatic disease
• Prior history of other disorders or complications caused by diseases
• Insulin therapy needed

Where it is running

• VA Medical Center — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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