Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers

Completed

Conditions studied: Extraocular Retinoblastoma, Intraocular Retinoblastoma, Recurrent Retinoblastoma

In brief

This laboratory study is looking at genetic mutations and environmental exposure in young patients with retinoblastoma and in their parents and young healthy unrelated volunteers. Gathering information about gene mutations and environmental exposure may help doctors learn more about the causes of retinoblastoma in young patients.

Key facts

Study ID

NCT00690469

Run by

Children's Oncology Group

People needed

234

Starts

2008-06-02

Last updated by the study team

2019-10-08

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Cases must meet the following criteria:
• Diagnosed with sporadic retinoblastoma (RB) on or after 07/01/2006
• No familial retinoblastoma
• Have permission of physician to contact the parents
• Diagnosed and/or treated at a Children's Oncology Group (COG) institution or *Wills Eye Hospital
• Controls must meet 1 of the following criteria:
• Mother of a child with unilateral RB
• Father of a child with bilateral RB
• Age-matched non-blood-related child if possible
• Must reside in the U.S. or Canada
• Must have telephone in the home
• Biological parent speaks English or Spanish
• Concurrent treatment on a therapeutic trial is NOT required

Where it is running

• Children's Hospital Central California — Madera, California, United States
• UCSF Medical Center-Mount Zion — San Francisco, California, United States
• UCSF Medical Center-Parnassus — San Francisco, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• Alfred I duPont Hospital for Children — Wilmington, Delaware, United States
• MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
• Nemours Children's Clinic-Jacksonville — Jacksonville, Florida, United States
• University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
• Nemours Children's Clinic - Orlando — Orlando, Florida, United States
• Nemours Children's Clinic - Pensacola — Pensacola, Florida, United States
• Sacred Heart Hospital — Pensacola, Florida, United States
• Johns Hopkins All Children's Hospital — St. Petersburg, Florida, United States
• Saint Joseph's Hospital/Children's Hospital-Tampa — Tampa, Florida, United States
• Saint Mary's Hospital — West Palm Beach, Florida, United States
• Children's Healthcare of Atlanta - Egleston — Atlanta, Georgia, United States
• Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
• Lurie Children's Hospital-Chicago — Chicago, Illinois, United States
• University of Illinois — Chicago, Illinois, United States
• Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
• University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
• Wayne State University/Karmanos Cancer Institute — Detroit, Michigan, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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