Identifying and Facilitating Ventricular Recovery on Mechanical Support

Completed

Conditions studied: Heart Failure

In brief

Heart failure is a progressive disorder in which the weakened heart is not able to efficiently pump blood throughout the body. When the body's cells do not receive enough blood, this can result in fatigue, shortness of breath, and difficulty carrying out daily activities. The left ventricular assist device (LVAD) is a device that is used to provide mechanical circulatory support to patients with end-stage heart failure who are awaiting heart transplants. Although LVAD support helps maintain the pumping ability of the heart and dramatically improves heart failure symptoms, the quality of life with LVAD support is far from ideal. It has been shown that LVAD support in selected patients may restore the failing heart enough to eliminate the need for heart transplant, but more information is needed to assess heart recovery and to guide weaning of LVAD support. Using data collected from patients who have undergone LVAD implantation, this study will attempt to better assess heart recovery and to generate criteria for identifying patients eligible for the removal of LVAD support.

Key facts

Study ID

NCT00687856

Run by

University of Pittsburgh

People needed

211

Starts

2008-04-01

Expected to finish

2014-07-01

Last updated by the study team

2023-10-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible to receive an LVAD or biventricular assist device (BIVAD) for clinical indications.

You may not qualify if…

• Refuses LVAD support
• Requires right ventricular assist device (RVAD) placement alone
• In atrial fibrillation with a ventricular response of greater than 120 beats per minute

Where it is running

• University of Maryland — Baltimore, Maryland, United States
• University of Michigan — Ann Arbor, Michigan, United States
• INTEGRIS Baptist Medical Center — Oklahoma City, Oklahoma, United States
• Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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